IDENTIFICATION, ISOLATION, AND THERAPEUTIC USES OF ENDOTHELIAL STEM CELLS THAT EXPRESS THE ABCG2+ SURFACE MARKER

摘要

Methods are provided for the isolation, expansion, enrichment, and transplantation of endothelial stem cells from blood vessels and induced pluripotent stem cells via the use of ABCG2 cell surface marker. The ability of the endothelial stem cells to expand in vitro and be subsequently implanted in vivo to generate new blood vessels provides a therapeutic hope for patients with numerous cardiovascular disorders (peripheral arterial disease, critical limb ischemia, ischemic retinopathies, acute ischemic injury to kidney, and myocardial infarction) where the lack of sufficient blood vessel forming ability in the patient limits their regenerative capacity.