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STRUCTURAL BASIS FOR OUTER MEMBRANE USHER ACTIVATION TO CATALYZE P PILUS ASSEMBLY
STRUCTURAL BASIS FOR OUTER MEMBRANE USHER ACTIVATION TO CATALYZE P PILUS ASSEMBLY
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机译:外膜活化的催化P组件的结构基础
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摘要
Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that disrupt the intramolecular interactions of the pilus subunits thereby reducing pilus assembly.
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