embedded image ;where Y is C1-C8 straight or branched chain alkyl, X is H, halo, C3-C4cycloalkyl or C1-C4alkyl and Z is H or fluoro, or a pharmaceutically acceptable salt thereof, shows surprising utility in the treatment of liver cancer or liver metastasis."/> SORAFENIB OR REGORAFENIB TROXACITABINE PHOSPHORAMIDATE PRODRUG COMBINATION THERAPY FOR LIVER CANCER
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SORAFENIB OR REGORAFENIB TROXACITABINE PHOSPHORAMIDATE PRODRUG COMBINATION THERAPY FOR LIVER CANCER

机译:肝癌索拉非尼或瑞戈非尼磷酸氧磷酰胺前药联合治疗

摘要

Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine with the formula:; embedded image ;where Y is C1-C8 straight or branched chain alkyl, X is H, halo, C3-C4cycloalkyl or C1-C4alkyl and Z is H or fluoro, or a pharmaceutically acceptable salt thereof, shows surprising utility in the treatment of liver cancer or liver metastasis.
机译:索拉非尼或瑞格非尼与曲沙他滨的氨基磷酸酯前药联合治疗,用下式: “嵌入式图像” ;其中Y为C 1 -C 8 直链或支链烷基,X为H,卤素,C 3 -C 4 环烷基或C 1 -C 4 烷基,并且Z为H或氟,或其药学上可接受的盐,在治疗肝癌或肝转移。

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