isolated antibody, composition, isolated nucleic acid molecule, vector, host cell, method for producing an antibody, hybridoma, methods for alleviating one or more symptoms of disease, and for decreasing or inhibiting hlight binding to man, ltbr, dcr3 or any combination thereof, and to decrease or inhibit the secretion of ccl20, il-8, rantes or any combination thereof, and, kit

摘要

isolated antibody, composition, isolated nucleic acid molecule, vector, host cell, method for producing an antibody, hybridoma, use of a composition, methods to decrease or inhibit the binding of hlight to man, ltbetar, dcr3 or any combination thereof, and to decrease or inhibit the secretion of ccl20, il-8, rants or any combination thereof, and antibodies, such as fully human antibodies, are provided herein that immunospecifically bind to a hlight polypeptide. isolated nucleic acids encoding antibodies, such as fully human antibodies, which immunospecifically bind to a hlight polypeptide are also provided. in addition, vectors and host cells are provided which comprise nucleic acids encoding antibodies, such as fully human antibodies, which immunospecifically bind to a hlight polypeptide. methods of making antibodies, such as fully human antibodies, that immunospecifically bind to a hlight polypeptide are also provided. also provided herein is a method of treating a hlight-mediated disease in a patient which comprises administering to the patient an antibody, such as a fully human antibody, which immunospecifically binds to a hlight polypeptide. In preferred embodiments, these anti-HIV antibodies hlight provided herein will improve, neutralize or otherwise inhibit the biological activity of hlight in vivo (e.g., hcl-mediated production or secretion of ccl20, il-8 or rant from a cell expressing a hlight receptor). also provided here is a method for detecting hlight in a sample as well as a method to improve, neutralize or otherwise inhibit hlight activity, for example, in a human patient suffering from a disorder in which hlight activity it's harmful.