modified giardia parasite protozoa and vaccine against protozoan infections

摘要

modified giardia parasitic protozoan and vaccine against infections produced by modified giardia protozoan parasitic protozoa comprising simultaneous expression on their surface of at least two variable surface proteins (vsp). The modified protozoan can also simultaneously express the full repertoire of variable surface proteins. protozoans show reduced expression of dicer, rna-dependent rna polymerase (rdrp) enzymes, or both, in which the rdrp gene and / or the dicer gene were silenced. protozoa may be any protozoa exhibiting a mechanism of antigenic variation.