A GENERAL THAT CODES A NOLOGY OF HUMAN R-FRUIT WITH RESPONSIBILITY TO MANUFACTURING AUTHORISATIONS IN MANUFACTURING AUTHORISATION HOLDERS IN 7P15-21 AND THEIR USES

摘要

The invention relates to a P-glycoprotein of the MDR family found on the human chromosome,with polynucleotide sequences,encoding this P-glycoprotein and fragments thereof. This gene is used in methods to determine the sensitivity of cancer cells to multi-drug resistance therapies,and in the design of diagnostic and therapeutic methods,related to resistance to multiple cancer medicines. This invention is also related to methods for determining whether a test compound can inhibit resistance to multiple drugs.