TUMOR-SELECTIVE MUTANTS OF TATA-BOXING AND CAAT-BOXING

摘要

The present invention relates, for example, to a recombinant virus comprising (i) a modified TATA box based promoter and / or (ii) a modified CAAT box based promoter operably linked to a gene, wherein the modified TATA box based promoter and / or the promoter based on the modified CAAT box lacks a functional TATA box and / or CAAT box, which allows the gene to be selectively expressed in a hyperproliferative cell. These recombinant viruses can be used to treat cell proliferative diseases and disorders, including some forms of cancer.