METHYLATION CLASSIFIER FOR IDENTIFICATION OF INVASIVE CANCER DISEASES INDUCED BY HPV, CANCER DISEASES OF FEMALE GENITAL ORGANS AND ANOGENITAL AREA NOT INDIVIDUAL OF HPV, AND THEIR EXTREME STEP

摘要

The present invention relates to a method for detecting high-grade precancerous lesions induced by HPV, invasive cancers induced by HPV, and cancers of the female genital organs and anogenital region not induced by HPV, comprising identifying a methylation classifier consisting of genes LHX8, ASCL1 and ST6GALNAC5 regulatory sequence in the cell, and such hypermethylation indicates the presence of HPV-induced progenitor lesions with invasive potential, invasive HPV-induced cancers, and cancers of the female genital organs and anogenital region not induced by HPV. The present invention also includes the use of a methylation classifier consisting of the LHX8, ASCL1 and ST6GALNAC5 genes and their regulatory sequences in such a method and an assay kit for detecting methylation of LHX8, ASCL1 and / or ST6GALNAC5.