2-ACETYL-6-(2-(2-(4-BROMOBENZYLIDENE)HYDRAZINYL)THIAZOLE-4-YL)-3,7,9-TRIHYDROXY-8,9b-DIMETHYLDIBENZOb,dFURAN-1(9bH)-ONE EXHIBITING AN INHIBITORY EFFECT ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME

摘要

The invention relates to molecular biology, biochemistry and biotechnology, and more particularly to the compound 2-acetyl-6-(2-(2-(4-bromobenzylidene)hydrazinyl)thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one, which is a hydrazinothiazolic derivative of usnic acid, having the formula I, and exhibits the ability to inhibit the activity of the human enzyme tyrosyl-DNA-phosphodiesterase 1. The technical result is an increase in the inhibitory effect on the human enzyme tyrosyl-DNA-phosphodiesterase 1 (Tdp1) and a broadening of the arsenal of agents which inhibit said enzyme.