首页> 外国专利> N-(5S,6S,9R)-5-AMINO-6-(2,3-DIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTABPYRIDIN-9-YL-4-(2-OXO-2,3-DIHYDRO-1H-IMIDAZO4,5-BPYRIDIN-1-YL)PIPERIDINE-1-CARBOXYLATE SALT

N-(5S,6S,9R)-5-AMINO-6-(2,3-DIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-CYCLOHEPTABPYRIDIN-9-YL-4-(2-OXO-2,3-DIHYDRO-1H-IMIDAZO4,5-BPYRIDIN-1-YL)PIPERIDINE-1-CARBOXYLATE SALT

机译:N-(5S,6S,9R)-5-AMINO-6-(2,3-二氟苯基)-6,7,8,9-四氢-5H-环己基[B]吡啶基-9-YL-4-(2 -OXO-2,3-二氢-1H-咪唑并[4,5-B]吡啶基-1-基)哌啶-1-羧酸盐

摘要

Disclosed is a hemisulfate salt of Compound (I): and crystalline forms of the hemisulfate salt. Also disclosed are methods of using the hemisulfate salt of Compound (1) as a CGRP receptor antagonist, and pharmaceutical compositions comprising the hemisulfate salt of Compound (I). The hemisulfate salt of Compound (I) is useful in treating, preventing, or ameliorating disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).
机译:公开了化合物(I)的半硫酸盐:和半硫酸盐的晶体形式。还公开了使用化合物(1)的半硫酸盐作为CGRP受体拮抗剂的方法,以及包含化合物(I)的半硫酸盐的药物组合物。化合物(I)的半硫酸盐可用于治疗,预防或改善疾病,包括偏头痛和其他头痛,神经源性血管舒张,神经源性炎症,热损伤,循环休克,与更年期相关的潮红,气道炎性疾病,例如哮喘和慢性阻塞性肺疾病(COPD)。

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