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Production method for cell mass including neural cells/tissue and non-neural epithelial tissue, and cell mass from same
Production method for cell mass including neural cells/tissue and non-neural epithelial tissue, and cell mass from same
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机译:包括神经细胞/组织和非神经上皮组织的细胞团的生产方法以及来自该细胞团的细胞团
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摘要
The present invention aims to provide a method for efficiently producing, from pluripotent stem cells, a cell mass containing a neural cell or neural tissue, and nonneural epithelial tissue. A method for producing a cell mass containing 1) neural cells or neural tissue and 2) nonneural epithelial tissue, including the following steps (1) and (2):(1) a first step of suspension-culturing pluripotent stem cells to form a cell aggregate in the presence of a Wnt signal transduction pathway inhibiting substance,(2) a second step of suspension-culturing the aggregate obtained in the first step in the presence of a BMP signal transduction pathway activating substance, thereby obtaining a cell mass comprising 1) neural cells or neural tissue and 2) nonneural epithelial tissue.
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