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Method of treating idiopathic thrombocytopenia purpura (itp) with romiplostim
Method of treating idiopathic thrombocytopenia purpura (itp) with romiplostim
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机译:romiplostim治疗特发性血小板减少性紫癜(ITP)的方法
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摘要
The present invention concerns a method of treating idiopathic thrombocytopenia purpura (ITP) in a patient having ITP, which comprises: (a) administering romiplostim weekly to the patient; (b) increasing the weekly dose until a platelet count of at least about 50 to 200 x 109/L is reached; (c) decreasing the weekly dose of romiplostim if the platelet count remains ≥ 200 x 109/L for two consecutive weeks; (d) discontinuing romiplostim if the platelet count has remained ≥ 200 x 109/L for two consecutive weeks when the weekly dose is 1 μg/kg or the platelet count is ≥ 400 x 109/L; and (e) if a platelet count ≥ 200 x 109/L is reached within the first 4 to 12 weeks of treatment, maintaining a treatment-free period of at least about 24 weeks during which the patient receives no romiplostim.
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机译:本发明涉及一种在患有ITP的患者中治疗特发性血小板减少性紫癜(ITP)的方法,该方法包括:(a)每周向该患者给药romiplostim。 (b)增加每周剂量,直到血小板计数至少达到约50至200 x 109 / L; (c)如果连续两周血小板计数保持≥200 x 109 / L,则降低罗莫司汀的每周剂量; (d)当每周剂量为1μg/ kg或血小板计数≥400 x 109 / L时,如果连续两个星期血小板计数连续≥200 x 109 / L,则停用罗莫司汀; (e)如果在治疗的前4至12周内血小板计数≥200 x 109 / L,则应维持至少约24周的无治疗期,在此期间患者不接受romiplostim。
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