ADAPTIVE ZONE MODEL PREDICTIVE CONTROL WITH A GLUCOSE AND VELOCITY DEPENDENT DYNAMIC COST FUNCTION FOR AN ARTIFICIAL PANCREAS

摘要

A system for the delivery of insulin to a patient is provided. The systems and methods disclose include an insulin delivery device configured to deliver insulin to a patient in response to control signals. The system also includes a controller programmed to receive the sensor glucose measurement signal from the glucose sensor. The sensor glucose measurement signal received indicates a concentration of the real time glucose concentration in a bloodstream. The controller is further configured to enact an impeding glycemia protocol based on a zone model predictive control (MPC) algorithm in response to the real time glucose concentration. The impeding glycemia protocol includes determining a relationship between predicted glucose concentrations, a rate of change of the predicted glucose concentrations, and a set of control parameters that determine insulin doses above and below a patient-specific basal rate.