NUCLEIC ACID FOR ENCODING HUMAN NADH DEHYDROGENASE SUBUNIT 4 PROTEIN AND APPLICATION THEREOF

摘要

Provided are a nucleic acid for encoding a human NADH dehydrogenase subunit 4 protein, and an application thereof; the nucleotide sequence thereof is as shown in SEQ ID NO. 1. Also provided is a fusion nucleic acid, containing the nucleic acid for encoding human NADH dehydrogenase subunit 4 protein. Further provided is a recombinant expression vector, containing the described nucleic acid or fusion nucleic acid. Also provided is a transformant, which introduces the described nucleic acid or fusion nucleic acid into the host. The nucleic acid for encoding human NADH dehydrogenase subunit 4 protein and application thereof has a higher expression; therefore more of the human NADH dehydrogenase subunit 4 protein can be obtained in mitochondria, thus Leber hereditary optic neuropathy can be better treated.