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ASCL2-RESPONSIVE REPORTERS FOR LABELING OF INTESTINAL STEM CELL ACTIVITY
ASCL2-RESPONSIVE REPORTERS FOR LABELING OF INTESTINAL STEM CELL ACTIVITY
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机译:ASCL2响应性报告,标记肠干细胞活性
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摘要
The invention pertains to a novel enhancer element that selectively controls expression in ASCL2-positive cells, such as intestinal and colon stem cells and stem cells in colorectal cancer.The invention further concerns a nucleic acid fragment and construct comprising this element as well as the use of the element in the treatment of a disease, especially a proliferative disease. The invention further relates to a method for detecting an ASCL2-positive cell and a cell comprising the enhancer element.
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