DEGRADATION DOMAIN MODIFICATIONS FOR SPATIO-TEMPORAL CONTROL OF RNA-GUIDED NUCLEASES

摘要

The disclosure includes non-naturally occurring or engineered CRISPR Cas variant proteins comprising one or more functional domains and degrader compositions specifically targeting the CRISPR Cas variant proteins; compositions, systems and methods of using the CRISPR Cas variant proteins comprising one or more functional domains and degrader compounds for spatio- temporal control are also provided.