Method for producing mesenchymal stem cells, therapeutic effect marker of mesenchymal stem cells, method for determining therapeutic effects of mesenchymal stem cells, and cellular preparation containing mesenchymal stem cells

摘要

[Problem] To provide a cellular preparation containing highly therapeutically effective mesenchymal stem cells (MSCs). [Solution] The present invention provides a method for producing activated MSCs, the method comprising a step for using a cell culture carrier having a three-dimensional structure consisting of fibers to culture MSCs in a medium containing an activating agent derived from a mammalian fetal appendage. Also, provided are: a therapeutic effect marker of MSCs, wherein the marker is selected from the group consisting of p16