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METHOD AND APPARATUS FOR IDENTIFYING CANDIDATE SIGNATURES AND COMPOUNDS FOR DRUG THERAPIES

机译:鉴定药物治疗的候选信号和化合物的方法和装置

摘要

The present invention provides a method and apparatus for analysing data relating to analysis of complex networks in order to identify target bioactivity signatures, for example proteins, and potential therapeutic actives, for example compounds, that are likely candidates for drug therapies. There is provided a computer-implemented method of identifying a subset of potential therapeutic agents from a plurality of potential therapeutic agents comprising the steps of: receiving a network of biological data; receiving footprint data in relation to the plurality of therapeutic agents; determining from the footprint data of each or a combination of the plurality of potential therapeutic agents a functional effect on the network of the each or a combination of potential therapeutic agents; and outputting potential therapeutic agents ranked based on the determined functional effects on the network.
机译:本发明提供了一种用于分析与复杂网络的分析有关的数据的方法和设备,以识别可能是药物治疗候选者的靶生物活性特征(例如蛋白质)和潜在的治疗活性物质(例如化合物)。提供了一种从多个潜在治疗剂中识别潜在治疗剂的子集的计算机实现的方法,包括以下步骤:接收生物学数据网络;以及接收与多种治疗剂有关的足迹数据;从多种潜在治疗剂中的每一种或组合的足迹数据中确定每种潜在治疗剂或组合的对网络的功能作用;并根据确定的网络功能作用对潜在的治疗剂进行排名。

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