COMBINING SERMS, SARMS, AND CANNABINOIDS FOR IMPROVING SAFETY AND EFFICACY OF ENDOCRINE THERAPIES

摘要

The present invention provides methods for the alleviation of symptoms of diseases or medical conditions impacted by dysfunction of the endocannabinoid system in a subject, the methods comprising administering an effective amount of a SERM, SARM, or other endocrine agent in combination with an effective amount of a cannabinoid or cannabimimetic agent or combination of such agents tailored to a subject's specific symptoms. In particular embodiments, the cannabinoid or cannabimimetic agent or combination of such agents alleviate chemotherapy-induced nausea and vomiting in a subject, while a prescription SERM treats the immuno-suppression associated with cannabinoid-based therapy. In some embodiments, the side effects associated with endocrine therapies in a subject are prevented or limited by administering cannabinoid or cannabimimetic agents or combinations of such agents to the subject. In other embodiments, the side effects associated with cannabinoid or cannabimimetic-based therapies in a subject are prevented or limited by administering a prescription endocrine therapy to the subject.