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BACTERIAL ENZYMATIC CONVERSION OF ANTHRACYCLINE CHEMOTHERAPEUTICS TO REDUCE TOXICITY AND PROMOTE DIVERSITY AMONG THE INTESTINAL MICROBIOTA
BACTERIAL ENZYMATIC CONVERSION OF ANTHRACYCLINE CHEMOTHERAPEUTICS TO REDUCE TOXICITY AND PROMOTE DIVERSITY AMONG THE INTESTINAL MICROBIOTA
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机译:蒽环类化学疗法的细菌酶转化,以减少肠道微生物的毒性并促进其多样性
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摘要
Disclosed are methods and compositions for treating a subject where the subject is undergoing or is about to undergo treatment with an anthracycline chemotherapeutic. In the disclosed methods, a subject may be administered an anthracycline chemotherapeutic and the subject further may be administered a detoxifying therapeutic agent that detoxifies the anthracycline chemotherapeutic, such as one or more enzymes that catalyze metabolism of the anthracycline chemotherapeutic or one or more probiotic organisms that express the one or more enzymes that catalyze metabolism of the anthracycline chemotherapeutic.
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