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METHOD OF TREATING A CHILD WITH CENTRAL PRECOCIOUS PUBERTY USING AN EXTENDED RELEASE COMPOSITION
METHOD OF TREATING A CHILD WITH CENTRAL PRECOCIOUS PUBERTY USING AN EXTENDED RELEASE COMPOSITION
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机译:使用扩展的释放成分治疗患有中央性早发性小儿的方法
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摘要
An extended release formulation is provided for use in a method for the treatment of Central Precocious Puberty (CPP) in pediatric patients 2 years of age or older. The extended release formulation comprises leuprolide or a pharmaceutically acceptable salt thereof, a biodegradable polymer, and a biocompatible organic solvent. The biodegradable polymer is comprised of poly(lactide-co-glycolide) (PLG) copolymer segments, poly(lactic acid-co-glycolic acid) (PLGA) copolymer segments, poly(lactide) (PL) polymer segments, poly(lactic acid) (PLA) polymer segments, or a combination thereof. The extended release formulation is administered as a subcutaneous injection of a flowable composition that forms a solid in situ depot. The extended release formulation releases leuprolide for a period of about 6 months for the effective treatment of CPP within a pediatric patient.
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