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Arginine deaminase encapsulated inside red blood cells and their use in the treatment of cancer and arginase-1 deficiency

机译：红细胞内封装的精氨酸脱氨酶及其在癌症和精氨酸酶-1缺乏症治疗中的应用

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摘要

The present invention relates to arginine deaminase encapsulated in red blood cells for use in therapy. Specifically, the present invention relates to its use in the treatment of arginase-1 deficiency. In addition, the present invention is a novel pharmaceutical composition comprising arginine deminase derived from M.arginini encapsulated in red blood cells and diseases in which arginine depletion may be beneficial, such as arginine dependent cancer, specifically arginine-nutrient composition It relates to cancer, and its use in the treatment of arginase-1 deficiency.

机译：本发明涉及封装在红细胞中用于治疗的精氨酸脱氨酶。具体地，本发明涉及其在精氨酸酶-1缺乏症的治疗中的用途。另外，本发明是一种新型药物组合物，其包含衍生自 M。精氨酸的精氨酸脱氨酶，所述精氨酸脱氨酶包封在红细胞和精氨酸耗竭可能有益的疾病中，例如精氨酸依赖性癌症，特别是精氨酸营养成分它涉及癌症，及其在精氨酸酶-1缺乏症治疗中的用途。 展开▼

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公开/公告号KR20200044822A

专利类型

公开/公告日2020-04-29

原文格式PDF

申请/专利权人 에리테끄 파르마;
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申请/专利号KR20207005870

发明设计人 듀푸흐 엠마뉴엘;블랑 마뉴엘;메이조 오렐리앙;
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申请日2018-06-29

分类号A61K38/50;A61K9/50;A61P31;A61P35;

国家 KR

入库时间 2022-08-21 11:07:14

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