CRIM1 CRIM1 single nucleotide polymorphism marker in gene for predicting risk of drug induced leukopenia and method for predicting risk of drug induced leukopenia using the same

摘要

The present invention relates to a composition for predicting the risk of developing drug-induced leukopenia including a monobasic polymorphic marker in the CRIM1 gene and a method for predicting the risk of developing drug-induced leukopenia using the same. The single nucleotide polymorphism marker in the CRIM1 gene according to the present invention has a high correlation with the risk of leukopenia induced by drugs, in particular, chipurin-based drugs, and thus, leukemia, Crohn's disease, ulcerative colitis, or Customized patient who can effectively predict or diagnose patients with high susceptibility to leukopenia occurring during chemopurine-based drug treatment such as organ transplantation, and achieve optimal treatment effect by administering the appropriate drug to the patient Treatment can be performed efficiently. Furthermore, the monobasic polymorphic marker according to the present invention can be used in drug development studies for the treatment of drug-induced leukopenia.