Bio-marker for non-invasive differential diagnosis of acute rejection in kidney transplanted patients and uses thereof

摘要

The present invention miR-4488, miR-4532, miR-146a-5p, miR-21-5p, miR-373-3p, miR-31-5p, miR-223-3p, miR-210- A marker composition for diagnosing an acute rejection of a kidney transplant comprising at least one miRNA selected from the group consisting of 3p and a combination thereof, a method for providing information necessary for diagnosing an acute rejection of a kidney transplant using the marker composition, the marker It relates to a diagnostic composition comprising an agent for measuring the expression level of, and a diagnostic kit comprising a quantitative device for the marker. MiR-4488, miR-4532, miR-146a-5p, miR-21-5p, miR-373-3p, miR-31-5p, miR-223-3p and miR-210-3p according to the present invention are kidney transplants Since acute rejection is present in the patient's urine at high levels, it can be used to conveniently diagnose acute rejection of kidney transplants in a non-invasive way.