TST56 RNA Modified RNA aptamer specifically binding to surface protein TST56 of the orientia tsutsugamushi Kato strain

摘要

The present invention relates to a modified RNA aptamer that specifically binds to the surface protein TST56 of Orientia Tsutsugamushi strain, which is a cause of Tsutsugamushi disease, one of the acute pyrogenic diseases in autumn. According to the present invention, there is provided a single-stranded nucleic acid aptamer comprising at least one nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 2 specifically binding to the surface protein TST56 of Orientia Tsutsugamu strain, and uracil of the base Modified RNA aptamer useful for the detection of Tsutsugamus bacteria, which is a major cause of Tsutsugassiosis, by having the nucleotide sequence of SEQ ID NO: 1 or 2 in which the 2 ''hydroxyl group of (U) and cytosine (C) is substituted with fluorine to provide.