PROX1 A composition for regulating expression or activity of telomerase reverse transcriptase comprising expression or activity regulators of PROX1 and a method for screening telomerase reverse transcriptase inhibitors

摘要

In the present specification, based on the correlation of PROX1 (prospero homeobox protein 1) and telomerase reverse transcriptase (TERT), a composition for regulating expression of TERT, a method for screening a TERT expression modulator, a composition for diagnosing TERT expression status, Disclosed is a diagnostic kit, a method for providing information for diagnosis, or a method for providing information for diagnosis of cancer. Specifically, in one aspect, PROX1 of the present invention can regulate the expression of TERT by binding to a TERT promoter, particularly a mutant TERT promoter in which a base substitution occurs at the -124 or -146 bp position, and among liver cancers, non-hepatitis B virus-derived liver cancer There is a feature that can specifically suppress the expression of my TERT. Accordingly, the present invention has an advantage that it can be utilized in various medical life fields, including a composition for regulating the expression of TERT, a composition for preventing or treating liver cancer derived from hepatitis B virus, and the like.