Urinary mRNA for non-invasive differential diagnosis of acute rejection in kidney transplanted patients and uses thereof

摘要

The present invention relates to a biomarker for diagnosing non-invasive kidney transplant acute rejection reaction and its use, specifically, at least one selected from the group consisting of C1QB, CD3ε, CXCL9, IP-10, Tim-3, PSMB9, and combinations thereof A marker composition for diagnosing acute kidney transplant rejection reaction comprising the mRNA of the gene as a marker, a method of providing information necessary for diagnosing acute kidney transplant rejection using the marker composition, for diagnosis including an agent measuring the expression level of the marker It relates to a diagnostic kit comprising a composition, and a quantification device for the marker. The mRNA of the C1QB, CD3ε, CXCL9, IP-10, Tim-3 and/or PSMB9 genes according to the present invention is present at a high level in the urine of patients with acute kidney transplant rejection, so a non-invasive method for acute kidney transplant rejection It can be used for simple diagnosis.