VACCINE STRAIN OF INFLUENZA VIRUS A/17/SLOVENIA/2015/1121 (H1N1)PDM09 FOR PRODUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN

摘要

FIELD: medical virology.;SUBSTANCE: vaccine strain A/17/Slovenia/2015/1121 (H1N1)pdm09 is a reassortant produced by crossing epidemic virus A/Slovenia/2903/2015 (H1N1)pdm09 with a cold-adapted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2) – an attenuation donor, which is harmless for humans. Strain A/17/Slovenia/2015/1121 (H1N1)pdm09 actively propagates in developing chick embryos at optimal temperature of 32 °C, characterized by temperature sensitivity, cold tolerance and harmlessness for laboratory animals. Reassortant has inherited genes coding surface antigens of haemagglutinin virus (HA) and neuraminidase (NA), from an epidemic parental virus and other six genes coding internal and non-structural proteins, from an attenuation donor.;EFFECT: strain can be used in practical health care for preventing the incidence of influenza in adults and children.;1 cl, 5 tbl