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METHOD OF TREATING PATIENTS WITH CANCER WITH SEVERE RENAL INSUFFICIENCY
METHOD OF TREATING PATIENTS WITH CANCER WITH SEVERE RENAL INSUFFICIENCY
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机译:治疗严重肾功能不全的癌症患者的方法
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摘要
FIELD: medicine; oncology; nephrology.;SUBSTANCE: group of inventions can be used for treating cancer in patients. That is ensured by oral administration of the combined drug into the patient. Means comprises α,α,α-trifluorothymidine (FTD) and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione hydrochloride in molar ratio 1:0.5. Patient has creatinine clearance less than 30 ml/min. Agent is administered in dose of 30–50 mg/m2/day in the form of an FTD-equivalent, dividing into two to four doses a day. What is also presented is use of a combined medicinal agent for preparing a therapeutic agent.;EFFECT: group of inventions provides treating cancer in patients with severe renal insufficiency.;14 cl, 1 dwg, 2 tbl, 1 ex
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机译:领域:医学;肿瘤学肾脏病学;物质:一组发明可以用于治疗患者的癌症。这是通过将组合药物口服给予患者来确保的。手段包括摩尔比为1:0.5的α,α,α-三氟胸苷(FTD)和5-氯-6-[(2-亚氨基吡咯烷-1-基)甲基]嘧啶-2,4(1H,3H)-二酮盐酸盐。患者的肌酐清除率低于30毫升/分钟。以相当于FTD的形式,以每天30–50 mg / m 2 Sup> /天的剂量给药,每天分为两至四剂。还提出了组合药物在制备治疗剂中的用途。效果:一组发明为患有严重肾功能不全的患者提供了治疗癌症的方法。14cl,1 dwg,2 tbl,1 ex
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