A complex comprising gold atom cluster and nucleic acid, preparation method thereof, and pharmaceutical composition for use in treating cancer or for photothermal therapy comprising the same

摘要

A complex comprising a gold atomic cluster and a nucleic acid, a method for preparing the same, and a pharmaceutical composition for treating cancer or photothermal treatment comprising the same, wherein the complex uses a nucleic acid having excellent biodegradability as a stabilizer and has a diameter of 0.3 for easy discharge Since it contains a -30nm gold atomic cluster, it has better biocompatibility than a conventional complex containing a polymer and gold nanoparticles having a particle size of several hundred nanometers as a stabilizer, and the diameter of the complex is adjusted to 30nm to 100μm to facilitate cancer tissue. It can penetrate, and by including thymine in the nucleic acid, the photothermal effect of the gold atomic cluster is improved, and the degree of photothermal heat can be controlled by adjusting the ratio of thymine in the nucleic acid sequence, so it can be usefully used for photothermal treatment, especially in the treatment of cancer. Can be.