A composition for early diagnosis of cardiovascular disease, a kit for early diagnosis of cardiovascular disease, and method for information for early diagnosis of cardiovascular disease

摘要

The present invention relates to a composition for early diagnosis of cardiovascular disease, a diagnostic kit comprising the same, and a method for providing information for predicting a high-risk group of cardiovascular disease. More specifically, as a novel biomarker selected in the present invention, peptide 1; m / z 625.30-> 616.30, peptide 2; m / z 770.35-> 778.35, peptide 3; m / z 789.06-> 1333.66 peptide 4; 4 peptides of m / z 1036.96-> 1018.57 showed that the subject had cardiovascular disease such as acute myocardial infarction (AMI), unstable angina (UA), or stable angina In this case, since the level (number) in these biological samples decreases, it is possible to compare the levels and diagnose the cardiovascular disease simply and accurately. Moreover, unlike the existing biomarkers that can only diagnose myocardial infarction, in the present invention, the peptide biomarkers of the present invention are used for predicting high-risk cardiovascular disease groups because they are distinguished from normal people with high specificity at the stage of unstable angina, which is a sign prior to the onset of myocardial infarction. Can be used in kits.