STRATÉGIE DE THÉRAPIE GÉNIQUE DESTINÉE À RESTAURER UNE FONCTION ÉLECTRIQUE ET CARDIAQUE, ET LA STRUCTURE CARDIAQUE, DANS UNE CARDIOMYOPATHIE VENTRICULAIRE DROITE ARYTHMOGÈNE

摘要

Disclosed herein are methods of treating arrhythmogenic right ventricular cardiomyopathy in a subject, comprising administering a gene therapy construct comprising a connexin 43 sequence, wherein as a result of the administration, connexin 43 levels in at least a portion of the heart are increased. Further disclosed are other cardiovascular diseases can be treated with the method.