An Orthogonal γPNA Dimerization Domain That Gives DNA Binders Cooperativity and Diversity Mimicking Transcription Factor Pairs

摘要

PROBLEM TO BE SOLVED: To provide a synthetic molecule capable of binding DNA and mimicking the synergistic action of a transcription factor (TF) pair. A molecule that is a programmable DNA binder pyrrole-imidazole polyamide (PIP) conjugated to a host-guest moiety for use in a general framework for mimicking cooperative TF-DNA interactions. , A molecule in which the cooperative module part is replaced with a left-handed (LH)γPNA module, ie PIP conjugated with a nucleic acid-based cooperative system. [Selection diagram] None