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REAGENZZUSAMMENSETZUNG ZUR MESSUNG VON GLYKIERTEM HÄMOGLOBIN UND VERFAHREN ZUR MESSUNG VON GLYKIERTEM HÄMOGLOBIN DAMIT
REAGENZZUSAMMENSETZUNG ZUR MESSUNG VON GLYKIERTEM HÄMOGLOBIN UND VERFAHREN ZUR MESSUNG VON GLYKIERTEM HÄMOGLOBIN DAMIT
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摘要
The present invention relates to a reagent composition for measuring glycated hemoglobin to diagnose the presence or absence of diabetes and a method of measuring glycated hemoglobin using the same, and more particularly to a reagent composition for measuring glycated hemoglobin, the composition including a dye-encapsulated silica nanoparticle-boronic acid, and to a method of measuring glycated hemoglobin using the same. The method of measuring glycated hemoglobin according to the present invention includes (a) introducing a blood sample into a reagent composition for measuring glycated hemoglobin, the composition including ① a hemolytic liquid and ② a "dye-encapsulated silica nanoparticle-boronic acid" specifically binding to the glycated hemoglobin, followed by hemolysis and reaction, (b) injecting a reactant into an absorption pad of a cartridge, followed by washing with a washing liquid, (c) measuring an optical reflectance of the absorption pad using an optical instrument to measure the amounts of total hemoglobin and glycated hemoglobin, and (d) calculating the ratio of the glycated hemoglobin on the basis of the measured amounts of total hemoglobin and glycated hemoglobin. In the reagent composition for measuring the glycated hemoglobin according to the present invention, since a dye is encapsulated in silica nanoparticles, the inherent absorption wavelength of the dye is not affected by pH and the composition has excellent stability even when stored for one month or more.
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