EXPRESSION RÉGULÉE PAR UN RÉGIME D'UN ACIDE NUCLÉIQUE CODANT POUR UNE PROTÉINE PRO-APOPTOTIQUE

摘要

The instant invention relates to nucleic acid comprising:- a regulatory polynucleotide comprising a minimal promoter and at least one AARE (amino acid response element) nucleic acid, said regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and- a suicide safety gene encoding an endogenously expressed and not secreted gene product associated with the killing of cells which is placed under the control of the said regulatory polynucleotidefor use in a method for eliminating in case of adverse events, infused cells comprising the said nucleic acid and administered to an individual in need of cancer treatment or regenerative medicine by inducing programmed cellular death into at least one said infused cell by submitting said individual to a diet deficient in at least one essential amino acid.