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BIOMARQUEURS POUR ÉVALUER L'ÉTAT DE RÉPONSE À UN TRAITEMENT D'UN ÉTAT OU D'UNE MALADIE INFLAMMATOIRE AFFECTANT LE TUBE DIGESTIF COMME UNE MALADIE INTESTINALE INFLAMMATOIRE CHEZ DES PATIENTS HUMAINS
BIOMARQUEURS POUR ÉVALUER L'ÉTAT DE RÉPONSE À UN TRAITEMENT D'UN ÉTAT OU D'UNE MALADIE INFLAMMATOIRE AFFECTANT LE TUBE DIGESTIF COMME UNE MALADIE INTESTINALE INFLAMMATOIRE CHEZ DES PATIENTS HUMAINS
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摘要
The invention relates to the identification of biomarkers of the response status of a patient for a treatment with anti-TNFalpha agents,for treatment with anti-α4β7 agents or with both anti-TNFalpha agent and anti-α4β7agents and to their use in assessing such status, in particular for assessing nonresponsive status for a treatment with anti-TNFalpha agents or respectively with anti-α4β7 agent in human patients suffering from inflammatory condition or disease, in particular Inflammatory Bowel Disease (IBD), in particular Ulcerative Colitis or Crohn's disease. The invention describes a method of in vitro assessing whether a treatment with anti- TNFalpha agent or with anti-α4β7 agent may be useful in a human patient suffering from inflammatory condition or disease, in particular when said condition or disease is a chronic and/or relapsing one, particularly a gastrointestinal, more particularly intestinal, inflammatory condition or disease which is eligible for treatment with anti-TNFalpha agent or respectively with anti-α4β7 agent. In a specific embodiment the method is suitable to assess whether such patient would be non- responsive to treatment with such anti-TNFalpha agent or respectively with anti-α4β7 agent and comprising determining a molecular signature in a biological sample previously obtained from said human patient.
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