ATLAS DE CELLULES DE TISSUS BARRIÈRES SAINS ET MALADES

摘要

Embodiments disclosed herein provide a cell atlas of barrier tissues from healthy and diseased subject. The atlas was obtained by single cell sequencing of approximately 18,036 cells in a surgical data set and 18,704 cells from scrapings. The present invention discloses novel markers for cell types. Moreover, genes associated with disease, including type 2 inflammation are identified. The invention provides for diagnostic assays based on gene markers and cell composition, as well as therapeutic targets for controlling differentiation, proliferation, maintenance and/or function of the cell types disclosed herein. In addition, novel cell types and methods of quantitating, detecting and isolating the cell types are disclosed.