UTILISATION DE MOLÉCULES INHIBITRICES DE LA SÉMAPHORINE-4D EN COMBINAISON AVEC UNE THÉRAPIE DE MODULATION IMMUNITAIRE POUR INHIBER LA CROISSANCE DE TUMEURS ET LES MÉTASTASES

摘要

Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of plexin-Bl-expressing cancer cells in a subject, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) in combination with an effective amount of at least one other immune modulating therapy.