INHIBITEURS DE SHMT2 ET DE MTHFD2 DE PREMIÈRE CATÉGORIE UTILISÉS COMME AGENTS ANTITUMORAUX

摘要

Pyrrolopyrimidine compounds and pharmaceutically acceptable salt thereof are provided. Pharmaceutical compositions having these compounds and acceptable pharmaceutical carriers are disclosed. Pyrrolopyrimidine compounds and pharmaceutically acceptable salts are set forth that are useful to treat a patient having pancreatic, colon, and lung cancers, to target mitochondrial metabolism, and to target serine hydroxymethyltransferase 2 (SHMT2) and 5,10-methylene tetrahydrofolate dehydrogenase 2 (MTHFD2).