INDUCTION DE CELLULES PROGÉNITRICES NEURALES, DE CELLULES PROGÉNITRICES D'OLIGODENDROCYTES ET D'OLIGODENDROCYTES PAR DIFFÉRENCIATION DE CELLULES SOUCHES À L'AIDE DE FACTEURS DE TRANSCRIPTION DE POINTS DE REPÈRE

摘要

A novel method of inducing neural progenitor cells, oligodendrocyte progenitor cells, oligodendrocytes from human iPSCs at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered transcription factors at multiple critical differentiation decision points along a pluripotent to ectoderm, neural ectoderm to NPCs to OPCs to oligodendrocytes pathway in a previously unknown manner.