Primjena sinbiotika u prijeoperacijskoj pripremi bolesnika za elektivnu operaciju debeloga crijeva Synbiotics application in the preoperative preparation of patients forudelective colorectal cancer surgery

摘要

AIM: The aim of our study was to demonstrate higher concentration of lactic acid bacteriaud(LAB) at the colonic mucosa in patients treated with oral intake of synbiotics. We also tried toudprove that the systemic inflammatory response after surgery is less severe in patients whoudeither took synbiotics or prebiotics and that these patients have less postoperativeudcomplications and a favorable postoperative course. ----- METHODS: 73 patients with preceding colorectal operations were recruited. They wereudrandomized into three groups. One group received preoperatively prebiotics, the secondudsynbiotics in and third was preoperatively cleansed. We have defined the number of fouruddifferent probiotic bacteria on colonic mucosa with polymerase chain reaction(PCR). Serumudlevels of interleukin-6, CRP, fibrinogen, white cell count and differential blood count wereudmeasured pre- and postoperatively to determine systemic inflammatory response. ----- RESULTS: We found out that in the synbiotic group there were considerably more LABudpresented on the mucosa. They did pass the upper gastrointestinal tract and were isolated inudcolonic mucosa. On the other hand, we did not find any statistical differences in systemicudinflammatory response measured by upper factors and no differences in postoperative courseudand complications rate between all three groups. ----- CONCLUSIONS: LAB used in our study reach the large bowel mucosa after oral intake butudin our case that didn’t seem to have an effect on postoperative course following colorectaludsurgery for cancer.