Morfološke i angiografske promjene periferne mrežnice u bolesnika sa senilnom makularnom degeneracijom Morphologic and angiographic peripheral retinal changes in patients with age relatedudmacular degeneration

摘要

Age related macular disease (AMD), are the most prominent cause of central visual acuityudloss in population older than 55 y.udWet form is more serious condition, because in short time, if not treated, central visual acuityudcan be permanently lost, so the estimation of the progression risk from dry to wet type,udbecomes important. Recent data suggest, that at retinal periphery, can exists some importantudmorphologic changes like peripheral drusen and reticular pigmentary changes, that usuallyudare connected more frequently with wet AMD form .udEstimation of disease progression has been usually done with standard fundus cameras thatudcan scan only the posterior pole and medial part of the retina which is approximately 45-50uddegree of all retina.udThe wide field camera which is used in this study, was able to scan almost 200 degree ofudretina, documented peripheral retinal changes and their angiographic characteristics.udThe aim of the study was to compare morphologic characteristics of peripheral retinal changesudin patients with AMD with healthy control group, and to compare morphologic andudangiographic characteristics of peripheral retinal changes between two types of AMD.udIn study was included 152 patients with signs of AMD and 150 healthy controls . Statisticallyudsignificant difference were observed in frequency of drusen, reticular pigmenteduddegenerations and „paving stone“ degenerations, which are more frequently observed inudAMD group.ud„White without pressure“ degeneration were more frequently observed in control healthyudgroup. Drusen are statistically significantly occurred and more widely spreaded in dry type ofudAMD .udThere were no statistically significant difference between wet and dry type of AMD, nor inudtype , frequency or localization of morphologic and angiographic characteristics of peripheraludretinal changes.