IgA腎症患者の末期腎不全進行における腎疾患関連遺伝子多型の影響

摘要

Background/Purpose: Polymorphisms found in genes encoding proinflammatory/profibrotic molecules have been demonstrated to be associated with several kinds of renal diseases. We investigated these polymorphisms in IgA nephropathy (IgAN) patients undergoing hemodialysis (HD) and their significance on progression to end-stage renal failure (ESRF). Methods: To evaluate the role of polymorphisms in genes described below, we analyzed the association of these polymorphisms with progression to ESRF in histologically-proven IgAN patients undergoing HD using Kaplan-Meier method. Employed genes are angiotensin-converting enzyme, angiotensinogen, monocyte chemoattractant protein-1, chemokine receptor (CCR5), transforming growth factor-β1, E-selectin (SELE), and L-selectin (SELL). Results: The duration between renal biopsy and ESRF (induction to HD) was significantly shorter in IgAN patients with T1402 allele at the SELE gene, G(-642) allele or T712 allele at the SELL gene than those without them. Any other polymorphisms were not significantly associated with progression to ESRF in this study. Conclusion: This work provides evidence that the T1402C polymorphism of the SELE gene, A(-642)G and C712T polymorphisms of the SELL gene are associated with rapid progression to ESRF in IgAN patients.