The effects of antibiotics on in-testinal microbiota and subse-quent recolonization using fecal microbiotic transplantation

摘要

This rapport describes how antibiotic treatment affect the human gut flora, and how a fecal micro-biotic transplantation can help recolonize the gut flora after such a treatment. The rapport explains how the gut microbiota is effected by treatments with antibiotics, and how a fecal microbiotic transplantation might help with recolonizing of the gut microbiota. To explain this, the report makes use of both reviews, academic books, and original research papers. The rapport looks at trials with antibiotic treated patients, and analyzes them. This analysis focuses on the period of recolonization for the gut flora. The trials show that treatment with antibiotics lower the diversity and changes the composition of bacteria, in the gut microbiota. Because of the lowered diversity, the gut microbiota is in a weakened state, this, in turn, affects the immune system, weakening it. This of course leaves the body susceptible to diseases until the gut flora has been recolonized. This period of recolonization varies but usually takes over a year. However it is not all patients who are able to recolonize their gut microbiota by themselves. A possible solution to this is fecal microbiotic transplantation. Since trials have shown that fecal microbiotic transplantation causes a new and more diverse microbiota very much like the one belonging to the donor. From these trials it is judged that fecal microbiotic transplantation is a method of treatment for patients not able to reestablish a balanced gut microbiota themselves. In the end, it is difficult to make a final conclusion but clear tendencies show that fecal microbiotic transplantation can help with the re-colonization of the gut microbiota.