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Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification of Trace-Level Host Cell Protein Impurities in Antibody Drug Products

机译：针对抗体药物产品中的痕量宿主细胞蛋白质杂质鲁棒定量的数据无关的采集方法的优化样品制备和数据处理

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Nicolas Pythoud; Joanna Bons; Geoffroy Mijola; Alain Beck; Sarah Cianférani; Christine Carapito;
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年度 2020
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1. Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins [J] . Esser-Skala Wolfgang, Segl Marius, Wohlschlager Therese, Analytical and bioanalytical chemistry . 2020,第24期

机译：探索样品制备及数据评估策略，提高治疗性抗体和FC融合蛋白的药物产品中宿主细胞蛋白的鉴定
2. Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development [J] . Husson Gauthier, Delangle Aurelie, OHara John, Analytical chemistry . 2018,第2期

机译：双数据无关的采集方法，在生物过程开发期间结合全球HCP分析和绝对量化的关键杂质
3. Sensitive methods for evaluation of antibodies for host cell protein analysis and screening of impurities in a vaccine process [J] . Lundstrom Christine Sund, Mattsson Anna, Lovgren Karin, Vaccine . 2014,第24期

机译：评估抗体的敏感方法，用于宿主细胞蛋白分析和疫苗过程中的杂质筛选
4. Simultaneous Quantitative Peptide Mapping and Host Cell Protein Detection in a Recombinant IgG1 Monoclonal Antibody Preparation using Data-Independent Acquisition [C] . Eric Johansen, Remco Van Soest, Sahana Mollah, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：使用数据无关的采集在重组IgG1单克隆抗体制剂中同时定量肽测绘和宿主细胞蛋白质检测
5. Host cell protein impurities and protein-protein interactions in downstream purification of monoclonal antibodies. [D] . Levy, Nicholas E. 2014

机译：单克隆抗体的下游纯化中宿主细胞蛋白质杂质和蛋白质间相互作用。
6. Identification and Characterization of Host Cell Protein Product-Associated Impurities in Monoclonal Antibody Bioprocessing [O] . Nicholas E. Levy, Kristin N. Valente, Leila H. Choe, -1

机译：单克隆抗体生物加工中与宿主细胞蛋白产物相关的杂质的鉴定和表征
7. Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins [O] . Wolfgang Esser-Skala, Marius Segl, Therese Wohlschlager, 2020

机译：探索样品制备及数据评估策略，提高治疗性抗体和FC融合蛋白的药物产品中宿主细胞蛋白的鉴定
8. Effect of Impurities and Processing on Silicon Solar Cells. Volume 1:Characterization Methods for Impurities in Silicon and Impurity Effects Data Base. [R] . hopkins, r. h. davis, j. r. 1980

机译：杂质和加工对硅太阳能电池的影响。第1卷：硅和杂质效应数据库中杂质的表征方法。

Optimized Sample Preparation and Data Processing of Data-Independent Acquisition Methods for the Robust Quantification of Trace-Level Host Cell Protein Impurities in Antibody Drug Products

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