首页> 外文OA文献 >Synthesis of N-{4-(2, 4-Diamino-5-methyl-4, 7-dihydro-3H-pyrrolo2, 3-dpyrimidin-6-yl)thiobenzoyl}-l-glutamic Acid and N-{4-(2-Amino-4-oxo-5-methyl-4, 7-dihydro-3H-pyrrolo2, 3-dpyrimidin-6-yl)thiobenzoyl}-l-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase and as Potential Antitumor Agents

【2h】

Synthesis of N-{4-(2, 4-Diamino-5-methyl-4, 7-dihydro-3H-pyrrolo2, 3-dpyrimidin-6-yl)thiobenzoyl}-l-glutamic Acid and N-{4-(2-Amino-4-oxo-5-methyl-4, 7-dihydro-3H-pyrrolo2, 3-dpyrimidin-6-yl)thiobenzoyl}-l-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase and as Potential Antitumor Agents

机译：N- {4 - （2,4-二氨基-5-甲基-4,7-二氢-3H-吡咯并2,3-D嘧啶-6-基）苯甲酰} -L-谷氨酸的合成和N- {4 - （2-氨基-4-氧代-5-甲基-4,7-二氢-3H-吡咯，2,3-D嘧啶-6-基）苯甲酰基-L-谷氨酸酸作为二氢酚酸还原酶和胸苷合酶的双抑制剂和潜在的抗肿瘤剂

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

著录项
相似文献
相关主题

著录项

作者

展开▼
作者单位

展开▼
年度 -1
总页数
原文格式 PDF
正文语种
中图分类

相似文献

外文文献
中文文献
专利

1. Synthesis of N-{4-[(2,4-Diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic Acid and N-{4-[(2-Amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic Acid as Dual Inhibitors of Dihyd [J] . Aleem Gangjee, Xin Lin, Roy L.Kisliuk, Journal of Medicinal Chemistry . 2005,第23期

机译：N- {4-[（2,4-二氨基-5-甲基-4,7-二氢-3H-吡咯并[2,3-d]嘧啶-6-基）硫代]苯甲酰基} -L-谷氨酸的合成和N- {4-[（2-氨基-4-氧代-5-甲基-4,7-二氢-3H-吡咯并[2,3-d]嘧啶-6-基）硫代]苯甲酰基} -L-谷氨酸酸作为二醛的双重抑制剂
2. Chemoenzymatic preparation of the novel antifolate thymidylate synthase inhibitor N-(4-{N-[(6S)-2-methyl-4-oxo-3, 4, 7, 8-tetra-hydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}-benzoyl)-L-glutamic acid and its glutamyl cleavage product [J] . Jonathan H. Marriott, Stephen Neidle, Zbigniew Matusiak, Journal of the Chemical Society, Perkin Transactions 1 . 1999,第11期

机译：新型抗叶酸胸苷酸合酶抑制剂N-（4- {N-[（6S）-2-甲基-4-oxo-3、4、7、8-四氢-6H-环戊[g]喹唑啉- 6-基] -N-（丙-2-炔基）氨基}-苯甲酰基）-L-谷氨酸及其谷氨酰胺裂解产物
3. SYNTHESIS AND BIOLOGICAL EVALUATION OF N-[4-(2-TRANS-[([2,6-DIAMINO-4(3H)-OXOPYRIMIDIN-5-YL]METHYL)THIO]CYCLOBUTY L)BENZOYL]-L-GLUTAMIC ACID A NOVEL 5-THIAPYRIMIDINONE INHIBITOR OF DIHYDROFOLATE REDUCTASE [J] . Varney MD., Boritzki T., Margosiak SA., Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 1995,第5期

机译：N- [4-（2-TRANS-[（[[2,6-diamino-4（3H）-OXOPYRIMIDIN-5-YL] METHYL）THIO] CLOBUTY L）BENZOYL] -L-谷氨酸的合成及生物评价二氢叶酸还原酶的新型5-噻吩并酮抑制剂
4. Design Synthesis and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethyl-thieno23-dpyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents [O] . Aleem Gangjee, Wei Li, Roy L. Kisliuk, -1

机译：设计合成和古典X射线晶体结构和非经典2-氨基-4-氧代-5-取代-6-乙基 - 噻吩并23-d嘧啶类如双胸苷酸合成酶和二氢叶酸还原酶抑制剂和潜在的抗肿瘤药物
5. Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno2,3-dpyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents [O] . Aleem Gangjee, Wei Li, Roy L. Kisliuk, 2009

机译：经典和非生物学2-氨基-4-氧代-5-取代-6-乙基硫胺2,3-D嘧啶的设计，合成和X射线晶体结构作为双胸苷合酶和二氢醇还原酶抑制剂和潜在的抗肿瘤剂

著录项

相似文献

相关主题

期刊订阅