No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT Study

摘要

Background: The Catechol-O-methyltransferase (COMT) gene contains a functionalpolymorphism, Val158Met, that has been found to influence human pain perception. In one studyfibromyalgia was less likely among those with Val/Val genotype.Methods: In the 1995–97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) wasevaluated in a random sample of 3017 individuals.Results: The distribution of the COMT Val158Met genotypes and alleles were similar betweencontrols and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Metgenotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similarbetween controls and the chronic MSCs groups.Conclusion: In this population-based study, no significant association was found between Val/Metpolymorphism at the COMT gene and chronic MSCs.