Biochemical Events during Initiation of Rat Hepatocarcinogenesis

摘要

Carcinogenesis is a multistep, multistage process that begins with irreversible,but heritable damage to a single cell. The partial hepatectomy/diethylnitrosamine (DEN) model of rat hepatocarcinogenesis has been well characterized and many aspects of the stage of initiation are known. In this manuscript male Fischer rats were subjected to a 70% partial hepatectomy and at the peak of cell proliferation 24 h later were adminsitered the solvent, trioctanoin, or 10 mg DEN/kg. The presence of 3 promutagenic adducts was seen during enhanced cellular proliferation and may contribute to the initiation that results in this model for hepatocarcinogenesis.