Health Effects of Acute Exposure to Air Pollution. Part 1: Healthy and Asthmatic Subjects Exposed to Diesel Exhaust. Part 2: Healthy Subjects Exposed to Concentrated Ambient Particles;Research rept. Jan 98-Jul 02

摘要

The purpose of the study was to assess the impact of short-term exposure to diluted diesel exhaust on inflammatory parameters in human airways. The authors previously exposed control subjects for 1 hour to a high ambient concentration of diesel exhaust (particle concentration 300 micrograms/cubic meters - a level comparable with that found in North Sea ferries, highway underpasses, etc). Although these exposures did not have any measurable effect on standard indices of lung function, there was a marked neutrophilic inflammatory response in the airways accompanied by increases in blood neutrophil and platelet counts. Endothelial adhesion molecules were upregulated, and the expression of interleukin 8 messenger RNA was increased in a pattern consistent with neutrophilia.