STUDIES ON PATHOGENESIS AND IMMUNITY IN LYMPHOCYTIC CHORIMENINGITIS INFECTION OF THE MOUSE

摘要

A study of pathogenesis and acquired immunity in lymphocytic choriomeningitis (LCM) in¬fection of adult mice has been carried out, with emphasis on determining the relation be¬tween virus growth and development of disease and developing procedures for demonstrating protective antibodies in immune mice. Evidence has been obtained that the degree of reactiv¬ity of the host to the growth of high titer virus is an important factor in the pathogenesis of the disease and in acquired immunity, and that the reactivity is modified by previous in¬fection, persistence of virus in the host, X-irradiation, and possibly by immune mouse serum.